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however, NICE has indicated that semaglutide may remain the preferred first-line GLP-1 agent in many formularies, owing to cost-effectiveness thresholds 3,16
For a deeper look at how these effects play out, the article on GLP-1 medications and inflammation covers the broader picture on joint and inflammatory outcomes
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The harder truth is that GLP-1s are a powerful tool, not a standalone solution without sustained lifestyle change, results are short-lived, and dropout rates climb
Your anatomy returns to exactly how it was before treatment
The effects of GLP-1 agonists on MASH may be indirect, resulting from reductions in calorie intake, body weight, and insulin resistance, all of which help decrease liver lipid accumulation and hepatic inflammation
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