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Excessive oxidation of GDH leads to a decrease of glutamate in hepatocytes, which in turn reduces the production of N-acetylglutamate (NAG), an allosteric activator of carbamoyl phosphate synthetase (CPS)

Intracellular GSH can detoxify H2O2 to water, thereby protecting membranes, protein, lipid, and the genome from oxidative damage

A proof-of-concept study of tanezumab was performed in 450 patients with knee OA