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Dose escalation should be individualised based on glycaemic response and tolerability
Spacing out administration may be beneficial if gastrointestinal side effects become problematic
They postulate the pain felt by patients is out of proportion to the damage seen, the pain is not just because cartilage over the bone gets worn down. They state the thin rim of the cartilage becomes inflamed and sends pain signals to the body
It also boosts your metabolism
Research suggests yes through direct effects on inflammatory pathways, gut health, insulin resistance, and oxidative stress that don't depend on losing weight, which is part of why low-dose "microdosing" can help
Curr Drug Targets Immune Endocr Metabol Disord (2004) 4:15766
