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However, by 48 hours PLI in the in vivo mouse lens fiber cell removal surgery model, variable amounts of enhanced fibrotic protein expression are associated with LECs including polymerized SMA, and fibrotic ECM molecules such as fibronectin and tenascin C (183, 185, 199)

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Thomas RH, Meeking MM, Mepham JR, Tichenoff L, Possmayer F, Liu S et al

Kelch-like ECH-associated protein 1 (Keap1) is believed to be the major repressor of NRF2, supported by the evidence that disruption of in the mouse increased the abundance and activity of NRF2 [9]