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Receptor trafficking involves the internalisation of the active receptor: Ligand complex towards endocytic compartments, followed by its deactivation/dephosphorylation and recycling back to the cell membrane, leading to its re-sensitisation, or trafficking to lysosomal organelles for its degradation and final signal termination (McGlone et al., 2021)

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14.9% mean weight loss with FDA-approved 2.4mg semaglutide over 68 weeks (directly applies to Ro-prescribed Wegovy): nejm.org/doi/full/10.1056/NEJMoa2032183 New England Journal of Medicine SURMOUNT-1 (Jastreboff et al., 2022)