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[3] Other common adverse effects reported during the clinical trials include back pain, upper respiratory tract infections, melanocyte naevus, decreased appetite, migraine, dizziness, weakness, fatigue, lethargy, sleepiness, hot flashes, abdominal pain, diarrhea, vomiting, flushing, development of warts, spots, and freckles, and itchy skin (between 1% and 10% of people)

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These compounds address underlying pathology including collagen disorganization, persistent inflammation, and impaired blood supply

B.CintoniM.PorcariS.RinninellaE.KaitsasF.et al (2023)

Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia Muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut

(2015) Morris et al