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Depression: A meta-analysis of 5 RCTs (n=574) found that NAC significantly improved depressive symptoms, particularly in individuals with high baseline symptom severity (Fernandes et al., J Clin Psychiatry, 2016) [73]

Methylation status can affect histamine clearance, antioxidant capacity, neurotransmitter regulation and the ability to manage inflammatory or metabolic stress

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As of September 2023 it is on the FDA Category 2 list of bulk drug substances that may not be compounded, and a PCAC review is scheduled for July 2026 under the name Emideltide