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doi:10.1038/s41574-018-0016-2 5

Gut peptide hormones such as GLP-1 could potentially also have an impact on appetite regulation by effects on gastric emptying and direct CNS effects, but we needed a robust methodology that could be used to measure acute effect of putative hormones on subjective appetite and spontaneous food intake

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However, because the control beverage elicited similar lipid-lowering effects in hypercholesterolemic participants, and due to the short study duration and small sample size, further research is needed to clarify yerba mates long-term efficacy, optimal dosing, and potential role in populations with chronic conditions such as type 2 diabetes, obesity, or advanced cardiovascular disease

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Tirzepatide timing Tirzepatide is far more forgiving