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The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme

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Evening application is commonly cited in cosmetic studies to align with overnight tissue repair cycles

doi: 10.1038/sj.bjp.0707462 51 JenhCHCoxMACuiLReichEPSullivanLChenSCet al

2014 Feb;13(1):812