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Research suggests, however, that health professionals may need to be more attentive to an often-ignored drug side effect: severe depression
Stress Response and Anxiolytic Models: In rodent elevated plus-maze, open-field, and restraint-stress models as well as small human trials, DSIP reduced behavioral signs of anxiety, lowered plasma cortisol/ACTH responses to stress, and normalized stress-induced alterations in catecholamine and serotonin turnover
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This is bad, especially when considering that satellite cells are essential for skeletal-muscle regeneration
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