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Six clinical trials enrolling ~900 participants demonstrated excellent safety but the pivotal Phase IIb trial failed to show clinically meaningful weight loss, leading to development termination in 2007
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NAC discussion gets really interesting
This, in part, reflects the challenge and mistrust of the medical establishment, which worsened during the Covid pandemic, but was already showing strong signs of opposition by the wide adoption of supplements (with a very similar lack of supportive data on efficacy and safety) long before 2020
Our results were in line with the in vivo data, that sulforaphane itself did not affect LC3-II expression, but significantly rescued the rotenone-inhibited expression of the protein
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