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Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex

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Subcutaneous and intraperitoneal routes give shorter circulating windows, with the compound clearing primarily through proteolytic degradation outside the GI tract rather than through renal or hepatic elimination as a single molecule

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It also has significant anti-inflammatory properties and supports gut mucosal integrity

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