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This was an unanticipated finding since TMAO is associated with cardiovascular and metabolic disease and AD and prior human studies showed modulation of plasma TMAO by the E4 allele (Vogt et al., 2018

In a study spanning 68 weeks, patients with an average BMI of 38.8 lost an average of 14.9% of their body weight

82,90,91,92 Adolescents exhibit a similar trajectory, with significant increases in osteocalcin and CTX observed between 6 and 12 months following VSG, although CTX tends to plateau after six months

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