The implications of this in people with Down syndrome need additional study
& Lee, S.-H
The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomalalso known as MAPEGproteins
Increased -SMA expression in primary lung fibroblasts from aged (24 months) C57BL/6 mice compared to young (8 months) C57BL/6 mice
The levels of glutathione depend on the mutation in question, and nrc1 , cad2-1 , pad2-1 and zir1 , which are affected in GSH1 show glutathione levels that range from 45 to 15% of normal levels 50,51,54,68
Each takes a different approach to the same fundamental problem, and understanding their distinct mechanisms helps you determine which one, or which combination, fits your situation