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PubMed Central , Clinical, Cosmetic and Investigational Dermatology , vol

AratakeTHigashiYHamadaTUebaYShimizuTShimizuSet alThe role of diurnal fluctuations in excitatory amino acid carrier 1 levels in post-ischemic hippocampal Zn2+ accumulation

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He acknowledges the research limitations, noting that much evidence comes from animal studies rather than human clinical trials

Animal studies have shown that the selective small-molecule inhibitor 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), targeting the key glycolytic enzyme Phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3), disrupts T cell metabolism, culminating in reduced cell proliferation and heightened cell death rates

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