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Nat Rev Endocrinol 13(5):278288

Any perceived weight loss benefits likely result from correcting an underlying deficiency causing fatigue, rather than from direct fat-burning mechanisms

The compounds effects on NAD+ metabolism may have implications for muscle biology given the importance of NAD+-dependent enzymes in muscle function

A small number of people also reported changes to their heart rhythm (arrhythmias) , though none of these were considered serious

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