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Exclusion criteria included (a) clinical studies that had menopause hormone therapy as a treatment, (b) case reports, (c) in vitro studies or (d) animal studies, and (e) duplicate articles or off-topic articles

This difference has practical implications for dosing

Testing MTHFR and other relevant genetic markers can identify these individuals, though routine genetic testing for b12 supplementation decisions remains controversial

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Frankly, my usual faves showed immediate results