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We did not query cytokine concentrations at earlier time points, and therefore cannot rule out the possibility that robust neuroinflammation occurred throughout the course of treatment or acutely after APAP administration to explain the cognitive deficit we observed

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ALT and AST levels are not reliable indicators of the presence or severity of NAFLD.(14) ALT and AST levels are not reliable indicators of the presence or severity of NAFLD. RISK STRATIFICATION Liver biopsy is the gold standard to stratify NAFLD and the only way to identify histologic ballooning to diagnose NASH