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Thereafter, we observed increased expression of cell death marker cleaved-caspase 3 upon sertraline as monotherapy in NCI-H125, NCI-H1975, NCI-H1299 and HCC15 cell lines, and the combination therapy in NCI-H125, NCI-H520, NCI-H1975, NCI-H1299 and HCC15 cell lines, highlighting the partial cytotoxic effect of sertraline and combination therapy (Supplementary Fig

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However, stronger and faster results also come with a greater risk of testosterone suppression, fertility problems, cardiovascular strain, liver concerns, mood changes and other systemic effects

On the other hand, some conditions require long-term or even lifelong supplementation