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It is a synthetic biguanide, originally derived from a guanidine compound found in Galega officinalis , a medicinal plant historically used to alleviate diabetic symptoms as early as the 18th century ( Initially, metformin attracted limited clinical interest due to its relatively low potency and the need for high doses to achieve therapeutic effects

Mannino, G., Gentile, C., Ertani, A., Serio, G

This medicine is used to treat vitamin B12 deficiency

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FASEB J Off Publ Fed Am Soc Exp Biol 15:14811483 Avery JC, Hoffmann PR (2018) Selenium, selenoproteins, and immunity

Oklahoma Agricultural Experiment Station Miscellaneous Publication