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For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

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Quick-Answer Summary Standard dose: 250500 mcg/day subcutaneous Cycle: 412 weeks Reconstitution: 2 mL bacteriostatic water per 5 mg vial Storage: refrigerated, 24 weeks stability Best for: tendon, ligament, muscle, and gut healing Top stack: BPC-157 + TB-500 for soft-tissue injuries

Per-Component Trial Evidence Retatrutide The Jastreboff et al

This usually subsides within a few days