Regulatory review, if trials conclude successfully, could still take several years
KG can generate acetyl-CoA, a metabolic precursor for lipid synthesis in the cytoplasm, and stimulate dihydrolipoamide dehydrogenase to produce mitochondrial ROS and increase local iron levels to promote ferroptosis [45]
However, the Cochrane review conducted by Showell et al
Institute for Health Metrics and Evaluation, GBD Results, Accessed 24 November 2024
The approaches work through different pathways and may produce synergistic benefits
As the bar chart clearly tells us from the 3rd line on the bottom of the graph, obesity leads the top 30 therapy areas by growth from 2022