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When GLP-1 binds to GLP-1R on the surface of -cells, cAMP-dependent PKA is activated and subsequently activates the downstream signal PI3K, which inhibits apoptosis in islet -cells by blocking the expression of the pro-apoptotic protein Bax (Li et al., 2021) (Figure 4)
Nissen notes that SURMOUNT-MMOs use of all-cause mortality instead of cardiovascular death, consistent with this post hoc analysis, signals a shift for cardiovascular outcome trials
For doses of 7.5mg or higher with a 5mg/ml concentration, many researchers find it more practical to switch to a higher concentration vial
10.1016/S0014-4886(03)00086-4 Exp
