Overall, although the overall absolute risk increase is small (27 cases per 10,000 persons treated per year), clinical practitioners should nevertheless take into account the potential risk of gallbladder or biliary diseases associated with GLP-1RAs, especially when used at higher doses, for longer durations, and for weight loss, and in case the patient has a history of lithiasis [64]
[13] Inositol is generally well-tolerated, with mild gastrointestinal symptoms (nausea, flatulence, diarrhoea) being the most commonly reported side effects, usually at higher doses
As such, reducing insulin resistance and supporting healthy weight are important goals in the overall treatment and management of PCOS ( 1 , 3 )
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When fluid retention increases, the space becomes tighter, potentially compressing the nerve