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patients should be advised to use a non-oral contraceptive method or add a barrier method for 4 weeks after initiation and each dose increase
Stable yet stochastic inheritance: eccDNAs are inherited through both somatic and germline pathways, including pollen-mediated and graft-transmissible transfers, enabling non-Mendelian transmission of traits (Koo et al., 2018, 2023
GLP-1 usersthose on medications like semaglutide (Ozempic, Wegovy, Trizepitide, to name a few)often face a sneaky side effect: muscle loss
This doesn't mean harm is certain, but it does mean you cannot extrapolate oral safety data to the IV route" [13]
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