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Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH

Relative photoluminescence intensity was then calculated from the ration between intensity at each time point to the initial intensity before irradiation

A: Usually, 3-6 sessions spaced 4-6 weeks apart yield optimal results

Nature Medicine, 30(6), 1639-1647

The gap between "active in cells and animals" and "safe and effective in humans at a defined dose" is exactly where many promising molecules fail

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