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The mechanism involves positive regulation of the expression of ALDHs and cytoprotective enzymes (e.g

GST non-enzymatic functions GSTs are also implicated as modulators of signal transduction pathways implicated in cell survival and apoptosis, where they control the activity of members of the mitogen-activated protein kinase (MAPK) family 24,25

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Instead, it is injected straight into the bloodstream to achieve maximum effectiveness

While the treatment with Ru(II)-OH or NP2 slightly elevated the ROS levels inside the hypoxic cancer cells, the treatment with NP4 showed a strong enhancement of ROS