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Whilst the mechanisms of altered lipid metabolism in FRDA are not completely understood it has been suggested that reduced PPAR expression and its transcriptional regulator PGC-1, could lead to reduced breakdown of lipids, specifically PUFAs, making them more readily available to undergo lipid peroxidation (Tamarit et al., 2016

People using insulin or a sulfonylurea may need additional blood-glucose monitoring

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Avoid shaking vigorously, as this may result in air bubbles or reduce the potency of the glutathione

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