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The progressive form, MASH, exhibits hepatocyte damage, inflammatory cell infiltration, and variable degrees of tissue fibrosis, with advanced fibrosis representing the predominant prognostic determinant for hepatic morbidity and mortality, as well as an additional risk factor for extrahepatic complications

The challenge facing this strategy is that monotherapies often have varying pharmacokinetics and pharmacodynamics including half-life [69], meaning that the balance of target-receptor agonism may vary over time when using two different agents with varying profiles

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Ipamorelin is a growth hormone releasing peptide, or GHRP

The demographic and clinical characteristics of all ICSRs are outlined in Table 2

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