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They worsen progressively without any improvement trend

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Hyperactivity of entorhinal cortical and hippocampal circuits are also thought to underlie neurodegenerative disorders, such as AD and mild cognitive impairment (MCI) (268272)

Instead, the peptides induce a local curvature of the lipid bilayer, with the pores partly formed by peptides and partly by the phospholipid head group

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Plasmids Plasmids and their characteristics used for the methods in the following sections, including the protein purification of HpTpx, HpTpx point mutants, HpGroEL and tpx knockout mutants, are summarized in Supplementary Table 8