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These situations are uncommon, but they deserve prompt attention

AbbVies approach was explicit: build sufficient density and complexity in the secondary patent portfolio that no biosimilar developer could confidently assess freedom to operate without years of litigation

Because both influence hepatic metabolism, so the article says baseline impairment raises the risk of adverse effects from the combination

A COA does not establish human-use safety, clinical efficacy, diagnostic suitability, veterinary applicability, or suitability for any non-research purpose

Focus on appetite regulation and metabolic adaptation

Antidiabetic drugs and non-alcoholic fatty liver disease: A systematic review, meta-analysis and evidence map