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This enabled us to assess whether the structural differences and conformational dynamics observed in the Cagri and rAmy bound AMYR structures alter the nature of Gs protein interaction (Supplementary Fig

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Diluted reagent was added to cells after treatment and incubated for 30 min at 37C

At 10mg/ml concentration (50mg + 5ml water), a 50mg vial provides: 25 doses at 2mg each 50 doses at 1mg each 16-17 doses at 3mg each This typically supplies 4-8 weeks of use depending on dosing frequency and amount

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Ohno M, Fornerod M, Mattaj IW