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Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy

6 ADVERSE REACTIONS ADVERSE REACTIONS SECTION The following serious adverse reactions are described below or elsewhere in the prescribing information: Risk of Thyroid C-cell Tumors [see Warnings and Precautions (5.1)] Severe Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.2)] Acute Kidney Injury Due to Volume Depletion [see Warnings and Precautions (5.3)] Acute Gallbladder Disease [see Warnings and Precautions (5.4)] Acute Pancreatitis [see Warnings and Precautions (5.5)] Hypersensitivity Reactions [see Warnings and Precautions (5.6)] Hypoglycemia [see Warnings and Precautions (5.7)] Diabetic Retinopathy Complications in Patients with Type 2 Diabetes Mellitus [see Warnings and Precautions (5.8)] Pulmonary Aspiration During General Anesthesia or Deep Sedation [see Warnings and Precautions (5.9)] 6.1 Clinical Trials Experience CLINICAL TRIALS EXPERIENCE SECTION Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

Compared to 28.5% (1,071 patients) in the non-GLP-1 RA cohort

Common symptoms include: Pain in the knee, particularly when twisting or rotating

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Hosoki, S