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Oral glutathione is inexpensive, safe, and convenient, though only 1015% is absorbed by the gut

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While Nrf2 and JAK2/STAT3 have protective roles, severe oxidative stress can also lead to their dysregulation or interaction with other pathways in ways that contribute to later-stage remodeling or inflammation (Mahdiani et al., 2022

In other words, GPX4 could help cancer cells evade death by eliminating oxidative stress, subsequently causing progression and poor prognosis

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