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In addition, certain medications can reduce the absorption (and therefore the benefits) associated with B12

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Serum B12 levels peak 12 hours post-injection and remain elevated for 710 days depending on dose and individual clearance rates

A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes (p=0.270)

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