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Because of the gap in our knowledge and the small absolute numbers seen in the trials, a systematic review and meta-analysis was conducted to determine if risks differ by indication (for diabetes vs weight loss), dose, or duration of treatment (4)

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Impaired spermatogenesis was not obvious, and mature spermatogenic cells were absent in groups C and D

For example, bariatric surgery could be a lower-cost and longer-lasting treatment for obesity, according to a study in JAMA Surgery