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Ye Z, Song H

Ozempic (semaglutide) affects reward pathways involved in appetite and alcohol craving, but alcohol reward also involves opioid signaling that GLP-1 medications may not directly target

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We found that three of the model-designed sequences are potent dual agonists with superior biological activity

The difference likely relates to the specific conformational changes each agonist induces in the receptor, which determines which G-protein pathways are preferentially activated

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