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Transl Stroke Res 12(5):905922
QF-QBB-RES-ACC-00205)
Semaglutide produces the most pronounced central appetite suppression and body weight reduction of any selective GLP-1R agonist establishing it as the reference compound for studying the central GLP-1R neurocircuitry mediating clinically significant weight loss biology
GI adverse effects (nausea, diarrhea, vomiting and constipation) were dose-related and occurred mainly during the early dose escalation period [3,4]
GLP-1 medications have been used safely for over 20 years in patients with type 2 diabetes
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