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ME1 and ME3 require NADP + and ME2 utilizes either NAD + or NADP + for their catalytic activities, thus NADPH can be produced by ME both directly and indirectly through the activity of the NNT that catalyzes the transfer of hydride ions from NADH to NADP + and produces NADPH in mitochondria
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What are their effects on gut physiology
High feverespecially during the first trimesterhas been associated with adverse outcomes, including neural tube defects and miscarriage
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