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For the ARISTOTLE trial population (apixaban for AF), the dose-reduction criteria require 2.5 mg twice daily when two or more of the following are present: age 80 years or older, body weight 60 kg or less, or serum creatinine 1.5 mg/dL or higher (Granger et al., NEJM 2011) [3]

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Maiseyeu A, Di L, Ravodina A, Barajas-Espinosa A, Sakamoto A, Chaplin A, et al

Theoretical study of copper binding to GHK peptide