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Metabolic flexibility Although glutamine is the primary carbon source for the TCA cycle in some cancer cells, replenishment of TCA cycle intermediates using alternative anaplerotic substrates reduces bioenergetic stress, thereby enabling resistance to inhibition of glutamine metabolism

(PubMed) Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A

Fujimoto J, Chow CW, Zhang J, Behrens C, Moran C, Little LD, Gumbs C, Antonoff MB, Vaporciyan AA, Swisher SG , Heymach JV, Lee JJ, Hong WK, Wistuba II, Futreal A

(Source 1) Additionally, it's important to follow dosing instructions or guidance from your healthcare provider