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While the bupropion in Contrave helps reduce hunger and improve energy and mood, the naltrexone blocks certain opioid receptors involved in the brains reward response to food

However, some compounding pharmacies offer oral versions, these formulations lack the rigorous FDA approval process, leaving questions about their effectiveness unanswered by clinical trials

A systematic review from Australias Hunter Medical Research Institute found that although diabetes and obesity drugs are linked to substantial weight loss, clinical trials have largely failed to report what people are actually eating while taking them. A reduction in body weight does not automatically mean a person is well-nourished or healthy, said Clare Collins, laureate professor of nutrition and dietetics at The University of Newcastle, in a press release

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Proper refrigeration and sterile handling become even more critical

Lower Risk of Hypoglycemia Unlike insulin, GLP-1s only activate when your blood sugar is high