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Joint protection during increased physical activity requires water
[1] [2] Whilst highly effective, gastrointestinal side effectsparticularly nausea and vomitingare amongst the most commonly reported adverse reactions
Given these concerns, the FDA approved a new warning label for PPS in June 2020 143 which states that: A detailed ophthalmologic history should be obtained in all patients prior to starting treatment with PPS
The absence of published bioavailability studies, coupled with theoretical limitations, suggests that berberine patches are unlikely to deliver therapeutically relevant amounts of the compound into systemic circulation
A research use only label does not automatically remove medicinal status where the wider presentation encourages personal use
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