Scientists found that GLP-1 receptor mRNA levels in the nucleus tractus solitarius (NTS) dropped after 1-2 weeks of treatment, matching when the drug started becoming less effective [24]
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Oxidative stress from pollution, smoking, and chronic inflammation can also stimulate melanin production by activating tyrosinase
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Chae H, Augustin R, Gatineau E et al (2020) SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans
When people ask if it "detoxes the liver," they are usually asking if it helps the liver stay healthy while it does its job