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Our study also found that NRF2, GPX4 and SOD1 expression levels were higher in the neoadjuvant chemotherapy-resistant group compared to the sensitive group, further supporting our hypothesis and demonstrating the adverse effects of GSH on chemotherapy in breast cancer patients
755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons
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Gastroenterology 135 (4), 13111321
Its selective mechanism means its adverse effects are confined almost entirely to the consequences of GH elevation itself rather than off-target hormonal activation
[PMID: 1086568] PubMed record related to this compound for laboratory literature review
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