This is not medication failure
But they also didn't get thin probably because there are specific cells in the vomit center that do not induce vomiting but are critical to weight loss
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Large Phase 3 randomized controlled trials specific to endometriosis and GLP-1 medications are described as being in "nascent stages." Until they are completed, we are working with biological plausibility, mechanistic evidence, and self-reported survey data, valuable but incomplete
doi: 10.1095/biolreprod.115.137539 164 SunZLiPWangXLaiSQiuHChenZet al
SPI-1005 - Is this Ebselen-based drug a Menieres Miracle? Menieres Without The Spin , Substack, 17 July 2026, Primary Clinical Trial Database: Sound Pharmaceuticals