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The model of the open state conformation was based on the cryo-EM structure of GLP-1GLP-1RGs (PDB: 5VAI) and the Fab7F38ECD complex of the Fab7F38GLP-1R crystal structure presented here, which were superimposed on their ECDs using PyMOL
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Subsequent studies have found glutathione deficiency in the substantia nigra is common in a number of other neurodegenerative conditions as well, including Alzheimer's disease
( Epub 20221215 )
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