As of June 2025, retatrutide has not received marketing authorisation from the MHRA or EMA and cannot be legally prescribed or dispensed in the UK outside of an authorised clinical trial
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"However, the agency is aware that some patients are turning to compounded versions of these drugs, which are not approved by the FDA," the agency said
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California Department of Health Care Services spokesperson Tessa Outhyse said in an email that the official advice to try those other approaches now is not meant to dismiss any past efforts, but to encourage Medi-Cal members to take a renewed, proactive, and medically supported approach with their healthcare provider that may appropriately include these additional options. But that may be unrealistic, said Kurt Hong, founding director of the Center for Clinical Nutrition at Keck School of Medicine of the University of Southern California