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N-terminal pro-brain natriuretic peptide (NT-proBNP) and hsCRP were log-transformed, and hence, treatment ratios at week 52 are reported

The trial achieved its primary endpoint by demonstrating a statistically significant and superior reduction in HbA1c at week 52 with both the 25 mg and 50 mg doses versus the 14 mg dose of oral semaglutide

When inflammatory cells release highly reactive nitrogen and oxygen species, repeated tissue damage and regeneration of tissue may cause permanent genomic alterations in proliferating epithelium, including point mutations, deletions, or rearrangements, and induce neoplastic transformation [193]

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These drugs are prescribed in patients who are unresponsive to metformin due to contraindications or intolerance