10.1038/nature04634 20 JacobsenD
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Both mutants responded to hydrogen peroxide and DTT similarly to the wild type, however, cho2 required a higher concentration of hydrogen peroxide than opi3 and the wild type (2 mM as opposed to 1 mM) for a significant decrease in growth to be observed ( Figure 5 )
Critically, this redox adaptation is a key mechanism of resistance to radiotherapy and many chemotherapeutic agents, such as cisplatin and doxorubicin, which depend on generating oxidative damage to exert their cytotoxic effects [33]
We have compiled some of the most pivotal functions of glutathione: It effectively counterbalances hydroxyl radicals, singlet oxygen, and superoxide radicals
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